We are very pleased to announce that the two $50,000 seed grants we funded through the IDSA Foundation have been awarded!
These innovative researchers will work to investigate the potential link between an infectious agent and Alzheimer’s Disease. We are encouraged by the pioneering spirit of all the applicants and congratulate Colette Cywes-Bentley, PhD, and Allison Aiello, PhD, MS. on their award accomplishment.
Colette Cywes-Bentley, PhD
Institution Affiliation: Brigham & Women’s Hospital, Harvard Medical School
Project titled: The Role for Pathogen Expressed PNAG in Alzheimer’s Disease.
“The focus of this investigation is to identify a link between bacterial exposures and AD inflammation characterized by beta-amyloid plaques. Many researchers intuit this connection, but establishing the link has thus far been elusive. It is our hope that by using poly-N-acetyl glucosamine (PNAG) as a marker, it may be possible to identify bacterial pathogens or their fragments, as factors in Alzheimer’s pathogenesis. It is exciting and an honor to have the financial and academic support of IDSA in this research.”
Allison Aiello, PhD, MS
Institution Affiliation: University of North Carolina, Chapel Hill
Project titled: The Role of Dementia-Associated Pathogen Burden in the Development of Alzheimer’s Disease (AD) and Other Dementias.
“We hypothesize the burden of dementia-associated pathogens may contribute to neurodegeneration, and specifically development of dementia. Using data from multiple aging cohort studies, we aim to examine the association between dementia-associated pathogen burden and development of incident AD and other dementias. Furthermore, we will test for mediation of this pathway by inflammatory profiles, given that inflammation is a known risk factor for AD. Finally, genetic risk for AD will be explored as a moderator of this pathway, specifically we will assess interactions with ApoE and other known genetic risk factors for dementia.”